Certified Transport Registered Nurse Certification Practice Exam

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Which of the following is used as a reversal agent for malignant hyperthermia?

Neostigmine
Dantrolene
Glycopyrrolate
Sugammadex

The correct answer is: Dantrolene

Dantrolene is specifically used as a reversal agent for malignant hyperthermia, a life-threatening condition typically triggered by certain anesthetic agents. This medication acts by inhibiting calcium release from the sarcoplasmic reticulum of skeletal muscle, thereby reducing muscle contraction and heat production. By decreasing the abnormal muscle metabolism associated with malignant hyperthermia, dantrolene helps stabilize the patient's condition and reduce the risk of further complications. In the context of the other agents listed, neostigmine is primarily an acetylcholinesterase inhibitor used to reverse neuromuscular blockages rather than addressing malignant hyperthermia. Glycopyrrolate serves as an anticholinergic agent that helps reduce secretions and counteract certain side effects of anesthesia, while sugammadex is a specific reversal agent for neuromuscular blockade induced by the drug rocuronium. Thus, while these medications play important roles in anesthesia and emergency care, dantrolene is uniquely suited for the urgent treatment of malignant hyperthermia.