Certified Transport Registered Nurse Certification Practice Exam

What is the shortest duration of action among the neuromuscular blockers?

1. Sugammadex

2. Pancuronium

3. Rocuronium

4. Succinylcholine

The correct answer is: Succinylcholine

Succinylcholine is known for its rapid onset and short duration of action compared to other neuromuscular blockers. It functions as a depolarizing neuromuscular blocker, which means it works by causing a rapid depolarization of the motor end plate at the neuromuscular junction, leading to muscle paralysis. The pharmacokinetics of succinylcholine are characterized by a brief action, typically lasting about 5 to 10 minutes because it is quickly hydrolyzed by plasma cholinesterase. This allows for quick recovery after administration, making it particularly useful in situations requiring rapid intubation or procedures where short-term muscle relaxation is necessary. In contrast, other neuromuscular blockers have longer durations of action. For instance, pancuronium is a non-depolarizing agent with a longer duration, often lasting 60 to 90 minutes. Rocuronium, while having a faster onset compared to some other non-depolarizing agents, still has a longer duration of action than succinylcholine, generally in the range of 30 to 60 minutes depending on the dose. Sugammadex, while it can reverse neuromuscular blockade, is not a neuromuscular blocker in itself and