Certified Transport Registered Nurse Certification Practice Exam

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What is meant by histotoxic hypoxia?

  1. Insufficient oxygen due to blood loss

  2. Reduced oxygen intake at high altitudes

  3. Poisoning affecting oxygen utilization in tissues

  4. Blood being unable to reach the tissues

The correct answer is: Poisoning affecting oxygen utilization in tissues

Histotoxic hypoxia refers to a condition where, despite adequate oxygen being delivered to the tissues via the bloodstream, those tissues are unable to utilize the oxygen effectively due to the presence of a toxin or harmful substance. The most common example of this is cyanide poisoning, which affects the cellular machinery responsible for using oxygen for metabolic processes. As a result, even though oxygen levels may be normal in the blood, the cells cannot perform aerobic metabolism, leading to cellular damage and potential organ dysfunction. This definition centers on the impairment of oxygen utilization rather than the oxygen delivery or intake itself, which distinguishes it from the other conditions described in the incorrect options. For instance, blood loss would lead to insufficient oxygen availability, high altitudes would decrease the amount of oxygen inhaled, and issues with circulation would prevent the blood from reaching tissues. However, histotoxic hypoxia is specifically the failure of tissues to metabolize oxygen due to toxicity, aligning with the details provided in the correct choice.